{"id":12348,"date":"2022-09-27T17:35:34","date_gmt":"2022-09-27T14:35:34","guid":{"rendered":"https:\/\/portal.pta.pdm.gr\/?post_type=project-announcement&#038;p=12348"},"modified":"2022-09-27T17:54:45","modified_gmt":"2022-09-27T14:54:45","slug":"eic-transition-challenge-rna-based-therapies-and-diagnostics-for-complex-or-rare-genetic-diseases","status":"publish","type":"project-announcement","link":"https:\/\/portal.pta.pdm.gr\/en\/project-announcement\/eic-transition-challenge-rna-based-therapies-and-diagnostics-for-complex-or-rare-genetic-diseases\/","title":{"rendered":"EIC Transition Challenge: RNA-based therapies and diagnostics for complex or rare genetic diseases"},"content":{"rendered":"<p class=\"wp-block-paragraph\">ExpectedOutcome:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">EIC Transition aims at maturing both your technology and business idea thus increasing its technology and market readiness. The expected outcomes of an EIC Transition project are a) a technology that is demonstrated to be effective for its intended application and b) a business model, its initial validation and a business plan for its development to market. It is also expected that the intellectual property generated by the EIC Transition project is formally protected in an adequate way.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For more details, see the WP 2022.Objective:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Proposals submitted to this EIC Transition Challenge call should focus on one or more of the following specific objectives:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>advance, beyond the state-of-the-art, RNA delivery methods, including robust mRNA formulations, that would enable effective and safe delivery of mRNA into the cells;<\/li><li>design, develop and preclinical validate of novel miRNAs (miRNA lncRNA, tRNA or siRNA-based) therapies for complex or rare genetic diseases;<\/li><li>develop and validate novel RNA-based diagnostics and RNA-based predictive biomarkers that would allow for early and more accurate diagnosis and for favourable or non- post-treatment prognosis, respectively.<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Scope:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">EIC Transition funds innovation activities that go beyond the experimental proof of principle in laboratory. It supports both the maturation and validation of a novel technology from the lab to the relevant application environments (by making use of prototyping, formulation, models, user testing or other validation tests) as well as explorations and development of a sustainable business case and business model towards commercialisation.Expected Impact:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The starting point in the project should be a preliminary technology or protocol of an RNA-based therapy for complex or rare genetic diseases with unmet medical needs that demonstrates, in a lab or preclinical context, the essential features that underpin the disruptive nature of the innovation (TRL 3-4). The endpoint in the project should be a completely functional version of the technology suitable for clinical validation (TRL5-6), supported by a sound and implementable commercialisation\/exploitation strategy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Proposals are expected to contribute to at least one of the following outcomes:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>novel technological solutions leading to more effective and safer RNA delivery methods applicable to a wide range of non-infectious diseases;<\/li><li>utilisation of RNAs to molecularly classify sub-types of different solid tumours that would allow for stratification of patients leading to more effective and precise treatments in complex diseases with high-unmet medical needs;<\/li><li>novel and sound ideas for the development and validation of RNA-based therapeutic platforms and drugs;<\/li><li>all the projects should lead to a sufficiently mature and sound data for being ready to be up taken to the (pre-) clinical trials.<\/li><\/ul>","protected":false},"template":"","meta":[],"program":[303],"call-status":[312],"type-of-action":[304],"class_list":["post-12348","project-announcement","type-project-announcement","status-publish","hentry","program-horizon-europe-horizon","call-status-anenergi","type-of-action-horizon-research-and-innovation-actions"],"toolset-meta":{"field-group-for-proskliseis-ergon":{"opening-date":{"type":"date","raw":"1643241600","formatted":"January 27, 2022"},"closing-date":{"type":"date","raw":"1668038400","formatted":"November 10, 2022"},"project-announcement-url":{"type":"url","raw":"https:\/\/ec.europa.eu\/info\/funding-tenders\/opportunities\/portal\/screen\/opportunities\/topic-details\/horizon-eic-2022-transitionchallenges-03;callCode=null;freeTextSearchKeyword=;matchWholeText=true;typeCodes=1;statusCodes=31094501,31094502,31094503;programmePeriod=2021%20-%202027;programCcm2Id=43108390;programDivisionCode=null;focusAreaCode=null;destination=null;mission=null;geographicalZonesCode=null;programmeDivisionProspect=null;startDateLte=null;startDateGte=null;crossCuttingPriorityCode=null;cpvCode=null;performanceOfDelivery=null;sortQuery=sortStatus;orderBy=asc;onlyTenders=false;topicListKey=topicSearchTablePageState"}}},"_links":{"self":[{"href":"https:\/\/portal.pta.pdm.gr\/en\/wp-json\/wp\/v2\/project-announcement\/12348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/portal.pta.pdm.gr\/en\/wp-json\/wp\/v2\/project-announcement"}],"about":[{"href":"https:\/\/portal.pta.pdm.gr\/en\/wp-json\/wp\/v2\/types\/project-announcement"}],"wp:attachment":[{"href":"https:\/\/portal.pta.pdm.gr\/en\/wp-json\/wp\/v2\/media?parent=12348"}],"wp:term":[{"taxonomy":"program","embeddable":true,"href":"https:\/\/portal.pta.pdm.gr\/en\/wp-json\/wp\/v2\/program?post=12348"},{"taxonomy":"call-status","embeddable":true,"href":"https:\/\/portal.pta.pdm.gr\/en\/wp-json\/wp\/v2\/call-status?post=12348"},{"taxonomy":"type-of-action","embeddable":true,"href":"https:\/\/portal.pta.pdm.gr\/en\/wp-json\/wp\/v2\/type-of-action?post=12348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}